Nick here from Shopify.
Good question as taxes can be confusing even on the best of days. The first thing I always suggest is to reach out to your local tax office or an accountant while getting this set up on your Shopify store. Your local tax office or a professional accountant would know better than anyone and especially for your area.
I did find a third party document which goes through the general requirements for New York Nexus sales tax which you can find here. Shopify also has a blog post explaining the Economic Nexus sales tax which you can see here. Another helpful document I found on what Nexus is and how it affects your small business can be found here.
I hope that helps and gives you some direction on some next steps as well as some information.
All the best, Nick
what triggers Nexus in New York is
1.Opening an office in New York
2.Storing inventory in a warehouse in New York
3.Having remote employees located in New York
As quoted from the NYS website
"If you operate a trade or business from your home, you have the same responsibilities as any other vendor making the same types of taxable sales in New York State. Whether you run your business from a store or your home, or whether you work full time or part time is not what determines your requirement to be registered for sales tax. Instead, whether or not you are required to register is based on what types of items you sell, or what kind of services you provide. If the items or services that you sell are subject to sales tax, you are required to register. This also includes items that you sell on a regular basis through online auction or other Web sites."
The answer is yes
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