Hyde here from Shopify. That's an interesting question!
While you could pause your store each weekend, it may be simpler to do the following:
You could simply inform your customers that you are closed on weekends in the announcement bar (most Shopify themes offer an announcement bar option, you simply navigate to Online Store > Themes > Customize > Header and activate the announcements bar).
Then you can activate the password page with an edited message as per this guide:
Here's how you can customize your password page. This will prevent customers from being able to place orders on your store over the weekend:
I hope this helps, let me know if you have any other questions.
All the best, Hyde