Building a theme/store from scratch. Options (liquid necessary? can I use react?)

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Hi. I've done some theme development before (editing and adding to existing themes), but am about to build a theme/store from scratch.

I am a js/react/react-native/backend developer and am into the idea of doing something [like this](, using react as a front end that uses shopify APIs. Is this a reasonable setup?

I read a forum post that suggested it would be much easier/more functional to just use the liquid templating engine and that a more dynamic setup might have issues with rate limits, etc.

Anyways, considering all that, what do you think? Anyone that has done this, what do you recommend?