Wholesale and B2C site- best Practices - Looking for efficiency

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I was wondering what apps other store owners are using out there that allow wholesalers and online B2C shopping.  It seems that the backend stuff gets a little convoluted especially once you start adding Net30 terms.  Things like inventory, marketing, using KIT, seem to not blend very well and differentiate between wholesalers and B2C customers. 

What are others using to manage the wholesale options, shipping, and marketing for these different customers?   

If any store owners could respond with what works well for them that would be great!