Thanks for sharing your query with us here in the Shopify Community.
I'd like to share some info on how you can set up your Shopify store's tax settings if you're based in Canada, but first I will need to clarify what we cannot provide support for here.
In terms of what taxes you should be collecting and paying, or any registrations you're required to make we would have to direct you to consult a qualified expert in your jurisdiction to ensure you're compliant with any local laws or ordinances.
Can you tell me a bit more about your business, what you're selling and who you're looking to sell to?
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