Difference between using API key for authentication or Access token

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I am trying to integrate shopify in my nest js APP. There I needed to provide access token and domain to connect with my shopify store. But on shopify, I'm able to see API key and API secret too. So i wanted to know what is the purpose of API key and secret key and how can we use them in node JS app.
I will be glad if anyone can share CURL for example API, where we can connect to shopify without using access token.

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