I've checked our logs and can see the errors you're referring to, it looks like they all occurred on Feb 13th on a single shop. Can you confirm if the request eventually completed for that store? If you haven't been able to get the request to complete, it's possible one or more of the orders in the set you're attempting to retrieve is very large, in the past we've seen the potential for issues if you attempt to retrieve a particularly large order along with the limit=250 param. If this is the case please let me know and we'll investigate further.
The other possibility is that the database for that store was having an issue at the time, which was resulting in timeouts through the API. In either case, the best way to mitigate timeouts is to lower the limit on your request, which results in retrieving a smaller dataset which is less likely to timeout.