Is it possible to create a theme-less Shopify app using node js and react js?

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Hi, Shopify I have an issue creating a Shopify app. I want to create an Application without using a Shopify theme and I want to use node js and react js as a backend and frontend respectively or any other frontend technology.

And also want to use it as an online store. Is it possible or note that create a Shopify app without using a theme if it is possible then suggest the best method and also give a complete guide,

Thanks

Gyan Prakash Singh