Couple ideas:
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Easiest way you can use Order Automator to automatically change location, request fulfillment, send custom email notifications, etc by setting up rules (if vendor = Vendor A then request fulfillment to Supplier A… or same thing but send them an email with their products in the order)
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You might be able to do this in order routing settings too if it’s not too complex: https://help.shopify.com/en/manual/fulfillment/setup/order-routing/understanding-order-routing