Hi @tina_thelabgirl ,
Good question!
In a case like this, you would need to have two separate storefronts. The reason for this is even if you could have two credit card processors active - there would be nothing to stop the different customers checking out on either gateway if they are both available on the checkout - meaning your US and Columbian sales wouldn’t be kept separate in any way. The other thing is only certain gateways are available in certain countries. So, for example, if you set up the store with a US Address - you couldn’t add gateways that are not available in the US then to keep them separate.