How can I post /cart/update.js on checkout in Shopify Plus?

I’m using Vanilla JS - so using the xhr method. But I’m running into this same issue. I’m trying to post a cart attribute after shipping has been selected and a customer clicks “Continue to payment”.

Console returns a 200 indicating it was successful and the Cart API Reference shopify provides doesnt indicate that we cant do a POST to the cart at checkout.

Pretty lost on this one.