How can we offer manual payment methods to global customers?

I see. This is not something that the Shopify platform can currently support, so I will be sure to pass this feedback on internally in the hopes that it may one day be something our developers can help resolve.

In the meantime, I would recommend that you consult with Shopify Experts who are a team of third-party developers who can make custom changes to your store on a contracted basis. They may be able to develop a custom solution for accepting specific cryptocurrencies or may have access to an already existing integration that I’m unaware of.