Hi. I bought a Dymo 4XL and it worked with Etsy, then I tried Shopify and could not figure out how to print labels 4 x 6. then someone on this feed said the option to change format from 8 x 11 to 4 x 6 was available after you purchase the label. Then next to the print shipping the option is there to change format. You change it to 4 x 6 labels. Then in print change the printing to the label printer and change the size to the size 4 x 6. The label should change to fit the whole print view then print.
Hope it works for you.