We need to know, how to update the price using only the handle or variant sku column.
Shopify does not provide a direct way to update the price using only the handle or variant SKU. However, you can query the product or variant ID using the handle or SKU. The REST API provides a productVariant query where you can filter by SKU. Then, once you have the product or variant ID, you can use the ProductUpdate mutation to update the price.
Hope this helps!