Setting up store pick up for certain items

I am setting up my brick and mortar store on Shopify along with my Dropshipping products I already have on my website. Is there a way to make my in store products available for pick up or shipping and then the Dropshipping products shipping only since they will be from outside vendors? Would love for my customers to be able to check out with both is that is an option.

Yeah should be doable because you can use Shipping Profiles to decide which products can select which shipping method (or no shipping method).

This will help: https://help.shopify.com/en/manual/shipping/setting-up-and-managing-your-shipping/shipping-profiles

Local pickup documentation: https://help.shopify.com/en/manual/sell-in-person/shopify-pos/order-management/local-pickup-for-online-orders