Hey there, @EdG10 . Thanks for jumping in on the thread!
You are able to use a third party card reader alongside Shopify POS to facilitate transactions. However, as third party readers aren’t directly supported by Shopify POS, the way it would work is that you would facilitate that transaction with your third party reader, which would be using a third party payment gateway. Then, you would keep a record of that transaction within Shopify POS. We have a help document here that goes over that information.
Essentially, using a supported, Shopify Card Reader allows everything to integrate very smoothly, and with Shopify’s in-house payment processor, Shopify Payments. You won’t be able to ‘reprogram’ the third party reader to integrate with Shopify Payments, but it is still equipment that you can use to facilitate transactions.