Nick here from Shopify. Taxes can be difficult to figure out on the best of days!
Can I ask what country you are based in? The tax set up for each country is different but Shopify has some help guides on taxes in general and for US/Canadian taxes and then non-US/Canadian taxes.
Is there something specific you need help with or just getting them set up? Hopefully, these guides help, but let me know if you have any other questions!
All the best, Nick