While loading shopify app it says ... myshopify.com refused to connect?

When we install the app , installs perfectly and loads perfectly but if the hosted app server restarts and try to open my app it says like myshopify.com refused to connect. If we check the log it says Oauth error, we are wondering why is loading perfectly for the first time after installation and not after some time. Would be grateful if somebody could provide the solution for this. Found the same issue on community and as suggested cleared the cache and all doesnot help us.

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